The Center For
Minimally Invasive Neurosurgery
Craniopharyngiomas
Craniopharyngiomas are epithelial tumors that arise from remnants of tissue present during the embryonic development of the foregut (Rathke’s pouch). Histologically similar to Rathke’s cleft cysts, they typically arise from or in the region of the pituitary stalk. As they grow they can compress or attach to the optic nerve, hypothalamus, frontal and temporal lobes of the brain as well as the adjacent blood vessels (eg internal carotid arteries) and cranial nerves. Tumor consistency is highly variable with some being primarily solid while others are cystic (fluid containing). Calification and cholesterol crystal are common associated histologic features. Common presenting symptoms include loss of vision and developmental or growth delay in children.
Treatment
A variety of treatment approaches have been developed. These include surgical excision, aspiration of the contents of the tumor, shunting procedures and various forms of radiation therapy. In many cases minimally invasive surgery through the nose (endonasal surgery) or eyebrow (supraorbital approach) have been very effective at extirpating craniopharyngiomas. In other cases surgery is limited by the tumors adherence to surrounding vitals structures. The exact approach for surgery and treatment depends on the specific radiographic features, growth characteristics, tumor constency, and location in each individual patient.